In martial arts, a knifehand strike is a strike using the part of the hand opposite the thumb (from the little finger to the wrist), familiar to many people as a karate chop (in Japanese, shutō-uchi). This refers to strikes performed with the side of the knuckle of the small finger. Suitable targets for the knifehand strike include the carotid sinus at the base of the neck (which can cause unconsciousness), mastoid muscles of the neck, the jugular, the throat, the collar bones, ribs, sides of the head, temple, jaw, the third vertebra (key stone of the spinal column), the upper arm, the wrist (knifehand block), the elbow (outside knifehand block), and the knee cap (leg throw).

In many Japanese, Korean, and Chinese styles, the knifehand is used to block as well as to strike.